3/28/2024 0 Comments Fl studio 20 reg file 629Several epidemiological studies indicated that cancer and cardiovascular diseases share common risk factors. Meta-analyses have indicated that the deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease, and several forms of cancer. Because of the role of GSTs in detoxifying xenobiotics and the products of oxidative stress, the effect of GST deletion has been investigated for numerous conditions. Also, GST genetic polymorphisms imply variations in enzyme activities that can result in oxidative stress susceptibility through alterations in GSH metabolism. The null genotypes (homozygous for the non-functional allele) of GSTM1 and GSTT1 have a decreased capability of detoxifying some carcinogens. Among them, both GSTM1 and GSTT1 are known to be polymorphic in humans and both of them have null alleles resulting from gene deletion. Eight classes of mammalian cytosolic GSTs are currently recognized, designated as alpha (A), mu (M), kappa (K), omega (O), pi (P), sigma (S), theta (T), and zeta (Z). Glutathione S-transferases (GSTs), a family of phase II enzymes found in all eukaryotic species, play a critical role in detoxifying both naturally occurring and xenobiotic compounds, including carcinogens, environmental toxins, and reactive oxygen species, by catalyzing the transfer and conjugation of glutathione.
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